Membrane Proteins: New Approaches to Probes, Technologies, and Drug Design

Using Cultural Probes to Inform the Design of Assistive Technologies

This paper discusses the practical implications of applying cultural probes to drive the design of assistive technologies. Specifically we describe a study in which a probe was deployed with homebased carers of people with dementia in order to capture critical data and gain insights of integrating the technologies into this sensitive and socially complex design space. To represent and utilise t...

New Approaches for 1 H - detection in complex Membrane Proteins

H-detection can greatly improve spectral sensitivity in biological ssNMR, thus allowing the study of more complex proteins. However, the general requirement to perdeuterate proteins critically curtails the potential of H-detection by the loss of non-exchangeable H, which are important probes for protein structure and function. This issue is exacerbated for membrane proteins, which are shielded ...

Progress on Membrane Distillation and Related Technologies

Chemogenomic approaches to rational drug design.

Paradigms in drug design and discovery are changing at a significant pace. Concomitant to the sequencing of over 180 several genomes, the high-throughput miniaturization of chemical synthesis and biological evaluation of a multiple compounds on gene/protein expression and function opens the way to global drug-discovery approaches, no more focused on a single target but on an entire family of re...

Cutting edge approaches to drug design

Going for gold To demonstrate the viability of this approach to manufacturing electrical circuitry, Kiehl’s team is investigating an assembly of gold nanoparticles into linear arrays on the DNA scaffolding. In their approach, a set of short DNA strands with different sequences are formed into DNA tiles that self-assemble into a DNA crystal.The particles are assembled onto the DNA scaffolding by...